While working with Wordpress Mu, I came accross an intresting delemma. I wanted to change the location of the main blog location, but it appeared that “/blog/” had to be the root for the location, untill I came accross a setting in the wp-config.php file. Around line 22 it defines VHOST. I found that if you set this to VHOSTSETTING then you are then able to change to location of the main blog. I did not notice this causing any problems with any other part of the site, but I did not fully investigate what changing this setting affects.